Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 1.00 |
| ▸ | PDGFRA | P16234 | 3/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 3/20 | 1.00 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.64 |
| ▸ | PAK4 | O96013 | 3/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 9/20 | 0.55 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12474005 | 1.00 | KDR (1.00) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL12473994 | 0.93 | PDGFRA (1.00) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL12473996 | 0.93 | PDGFRA (1.00) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL30685915 | 0.83 | KDR (0.70) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL5368286 | 0.81 | PAK4 (0.69) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL14519103 | 0.79 | TLK2 (0.82) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL16568378 | 0.79 | TLK2 (0.82) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL5362637 | 0.78 | TLK2 (0.77) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL5361474 | 0.78 | TLK2 (0.70) | KDRPDGFRAPDGFRBTLK2PAK4 | |
| SCHEMBL5369648 | 0.76 | TLK2 (0.74) | KDRPDGFRAPDGFRBTLK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | claimed |