Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 3/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475272 | 1.00 | CTNNB1 (0.39) | CTNNB1PSMB5PSMB1CTSLCTSS | |
| SCHEMBL12475334 | 0.94 | SLC1A3 (0.37) | CTNNB1ESRRG | |
| SCHEMBL12475350 | 0.94 | SLC1A3 (0.37) | CTNNB1ESRRG | |
| SCHEMBL12475180 | 0.91 | CTNNB1 (0.37) | CTNNB1PSMB5PSMB1CTSLCTSS | |
| SCHEMBL12475174 | 0.91 | CTNNB1 (0.37) | CTNNB1PSMB5PSMB1CTSLCTSS | |
| SCHEMBL16384606 | 0.89 | CTNNB1 (0.36) | CTNNB1PSMB5PSMB1CTSLCTSS | |
| SCHEMBL17667532 | 0.87 | CTNNB1 (0.36) | CTNNB1PSMB5PSMB1CTSLCTSS | |
| SCHEMBL16384198 | 0.87 | CTNNB1 (0.36) | CTNNB1PSMB5PSMB1CTSLCTSS | |
| SCHEMBL12475082 | 0.87 | CTNNB1 (0.36) | CTNNB1PSMB5PSMB1CTSLCTSS | |
| SCHEMBL12475084 | 0.87 | CTNNB1 (0.36) | CTNNB1PSMB5PSMB1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673281-B1 | BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF | REMPEX PHARMACEUTICALS INC (US) | 2016-04-13 | — | — | EP | disclosed |
| EP-2673281-B1 | BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF | REMPEX PHARMACEUTICALS INC (US) | 2016-04-13 | — | — | EP | disclosed |
| US-8933018-B2 | Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2015-01-13 | — | — | US | disclosed |
| EP-2673281-A1 | BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF | Rempex Pharmaceuticals, Inc. (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012109164-A1 | BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF | REMPEX PHARMACEUTICALS, INC. (US) | 2012-08-16 | — | — | WO | disclosed |