Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475995 | 0.92 | AKT1 (1.00) | AKT1 | |
| SCHEMBL18166230 | 0.92 | AKT1 (1.00) | AKT1 | |
| SCHEMBL18166232 | 0.92 | AKT1 (1.00) | AKT1 | |
| SCHEMBL12476220 | 0.84 | AKT1 (1.00) | AKT1 | |
| SCHEMBL18166250 | 0.83 | AKT1 (1.00) | AKT1 | |
| SCHEMBL12476156 | 0.83 | AKT1 (0.82) | AKT1 | |
| SCHEMBL12475803 | 0.83 | AKT1 (1.00) | AKT1 | |
| SCHEMBL18166244 | 0.83 | AKT1 (1.00) | AKT1 | |
| SCHEMBL18166222 | 0.81 | AKT1 (1.00) | AKT1 | |
| SCHEMBL12475840 | 0.81 | AKT1 (1.00) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2658844-A1 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI (FR) | 2013-11-06 | — | — | EP | disclosed |
| WO-2012089633-A9 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI (FR) | 2012-08-23 | — | — | WO | disclosed |
| WO-2012089633-A1 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI (FR) | 2012-07-05 | — | — | WO | disclosed |