Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 20/20 | 0.55 |
| ▸ | ACE | P12821 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11969967 | 1.00 | MME (0.55) | MMEACE | |
| SCHEMBL11969755 | 0.90 | MME (0.58) | MMEACE | |
| SCHEMBL12481558 | 0.89 | MME (0.68) | MMEACE | |
| SCHEMBL11969919 | 0.89 | MME (0.68) | MMEACE | |
| SCHEMBL11970092 | 0.82 | MME (0.56) | MMEACE | |
| SCHEMBL11969621 | 0.82 | MME (0.67) | MMEACE | |
| SCHEMBL11969666 | 0.81 | MME (0.62) | MME | |
| SCHEMBL11969720 | 0.81 | MME (0.56) | MMEACE | |
| SCHEMBL11969970 | 0.81 | MME (0.56) | MMEACE | |
| SCHEMBL11969936 | 0.79 | MME (0.54) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675795-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-12-25 | — | — | EP | disclosed |
| WO-2012112742-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-08-23 | — | — | WO | disclosed |