Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.68 |
| ▸ | ACE | P12821 | 4/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11969639 | 1.00 | MME (0.68) | MMEACEPPARGPPARA | |
| SCHEMBL19788107 | 1.00 | MME (0.68) | MMEACEPPARGPPARA | |
| SCHEMBL18922352 | 0.93 | MME (0.58) | MMEACEPPARGPPARA | |
| SCHEMBL20681844 | 0.93 | MME (0.58) | MMEACEPPARGPPARA | |
| SCHEMBL15468089 | 0.89 | MME (0.67) | MMEACE | |
| SCHEMBL12480889 | 0.83 | MME (0.67) | MMEACE | |
| SCHEMBL11969828 | 0.83 | MME (0.67) | MMEACE | |
| SCHEMBL19788105 | 0.83 | MME (0.67) | MMEACE | |
| SCHEMBL19687934 | 0.82 | MME (0.65) | MMEACE | |
| SCHEMBL19788108 | 0.82 | MME (0.53) | MMEPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675795-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2013-12-25 | — | — | EP | disclosed |
| WO-2012112742-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-08-23 | — | — | WO | disclosed |