Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12484020 | 0.91 | CHRNA7 (0.57) | CHRNA7PTGS1PTGS2CA2CA1 | |
| SCHEMBL12483079 | 0.91 | CHRNA7 (0.60) | CHRNA7PTGS1PTGS2CA2CA1 | |
| SCHEMBL12483720 | 0.88 | CHRNA7 (0.77) | CHRNA7PTGS1PTGS2CA2SOS1 | |
| SCHEMBL12483675 | 0.88 | CHRNA7 (0.76) | CHRNA7PTGS1PTGS2CA2CA1 | |
| SCHEMBL12482858 | 0.87 | CHRNA7 (0.56) | CHRNA7PTGS1PTGS2CA2CA1 | |
| SCHEMBL12483588 | 0.87 | CHRNA7 (0.60) | CHRNA7CA2CA1CA9CA12 | |
| SCHEMBL12483956 | 0.87 | CHRNA7 (0.59) | CHRNA7PTGS1PTGS2CA2SOS1 | |
| SCHEMBL12483144 | 0.86 | CHRNA7 (0.60) | CHRNA7PTGS1PTGS2CA2CA1 | |
| SCHEMBL12484141 | 0.85 | CHRNA7 (0.53) | CHRNA7PTGS1PTGS2CA2CA1 | |
| SCHEMBL12483858 | 0.84 | CHRNA7 (0.59) | CHRNA7PTGS1PTGS2CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678327-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | Lupin Limited (IN) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012114285-A9 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012114285-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-08-30 | — | — | WO | disclosed |