Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.64 |
| ▸ | HSP90AB1 | P08238 | 14/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1585986 | 0.85 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1 | |
| SCHEMBL1586727 | 0.84 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1 | |
| SCHEMBL2268263 | 0.80 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1 | |
| SCHEMBL2271305 | 0.78 | HSP90AB1 (1.00) | HSP90AA1HSP90AB1 | |
| SCHEMBL1586688 | 0.78 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 | |
| SCHEMBL2271316 | 0.77 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1 | |
| SCHEMBL12368042 | 0.72 | HSP90AB1 (0.88) | HSP90AA1HSP90AB1 | |
| SCHEMBL12368061 | 0.71 | HSP90AB1 (0.87) | HSP90AA1HSP90AB1 | |
| SCHEMBL2263140 | 0.70 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL3705974 | 0.70 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012116061-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH RADIOTHERAPY | SYNTA PHARMACEUTICALS CORP. (US) | 2012-08-30 | — | — | WO | claimed |