SCHEMBL12486998

SCHEMBL12486998

O=C(O)c1ccc(N2CC3(CCN(Cc4cc(Br)c(Cl)c(Br)c4)CC3)OC2=O)cc1

nearest known ligand 0.69

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SSTR5 P35346 20/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL671856 0.90 SSTR5 (0.69) SSTR5
SCHEMBL671258 0.89 SSTR5 (0.58) SSTR5
SCHEMBL14969660 0.89 SSTR5 (0.67) SSTR5
SCHEMBL669379 0.86 SSTR5 (0.74) SSTR5
SCHEMBL672565 0.85 SSTR5 (0.73) SSTR5
SCHEMBL17612781 0.85 SSTR5 (0.62) SSTR5
SCHEMBL14956946 0.85 SSTR5 (0.60) SSTR5
SCHEMBL671267 0.83 SSTR5 (0.74) SSTR5
SCHEMBL15756175 0.83 SSTR5 (0.58) SSTR5
SCHEMBL674794 0.82 SSTR5 (0.65) SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2605658-A1 SPIROXAZOLIDINONE COMPOUNDS Merck Sharp & Dohme Corp. (US) 2013-06-26 EP disclosed
WO-2012024183-A1 SPIROXAZOLIDINONE COMPOUNDS MERCK SHARP & DOHME CORP. (US) 2012-02-23 WO disclosed