Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 10/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486174 | 0.89 | SCN9A (0.53) | SCN9ACCNT1CCNE2CCNE1CDK2 | |
| SCHEMBL12486402 | 0.89 | CCNT1 (0.49) | POLBSCN9ACCNT1CCNE2CCNE1 | |
| SCHEMBL12485723 | 0.89 | CA12 (0.52) | POLBCA12CA1CA2CA9 | |
| SCHEMBL12487189 | 0.88 | USP2 (0.49) | USP2SMN1; SMN2POLBCA12CA1 | |
| SCHEMBL12485572 | 0.81 | CCNT1 (0.54) | SMN1; SMN2SCN9ACCNT1CCNE2CCNE1 | |
| SCHEMBL12487113 | 0.80 | CDK2 (0.53) | SMN1; SMN2SCN9ACCNT1CCNE2CCNE1 | |
| SCHEMBL12486627 | 0.77 | CCNT1 (0.50) | SCN9ACCNT1CCNE2CCNE1CDK2 | |
| SCHEMBL12487046 | 0.75 | CCNT1 (0.43) | SCN9ACCNT1CCNE2CCNE1CDK2 | |
| SCHEMBL12486620 | 0.75 | SCN9A (0.67) | SCN9A | |
| SCHEMBL12487169 | 0.74 | SCN9A (0.51) | SCN9ACCNT1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2680852-A1 | PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES | Lead Discovery Center GmbH (DE) | 2014-01-08 | — | — | EP | claimed |
| WO-2012117048-A1 | PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES | LEAD DISCOVERY CENTER GMBH (DE) | 2012-09-07 | — | — | WO | claimed |