Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174948 | 0.85 | SYK (0.42) | AURKANTRK1SYKPAK4JAK1 | |
| SCHEMBL14432758 | 0.76 | NTRK1 (0.47) | AURKANTRK1PAK4JAK1 | |
| SCHEMBL174435 | 0.75 | AURKA (0.50) | AURKAGRK6NTRK1PAK4JAK1 | |
| SCHEMBL173552 | 0.75 | JAK2 (0.58) | AURKAIGF1RGRK6NTRK1SYK | |
| SCHEMBL174031 | 0.75 | JAK2 (0.58) | AURKAIGF1RGRK6NTRK1SYK | |
| SCHEMBL174030 | 0.75 | JAK2 (0.58) | AURKAIGF1RGRK6NTRK1SYK | |
| SCHEMBL10224893 | 0.75 | JAK2 (0.58) | AURKAIGF1RGRK6NTRK1SYK | |
| Hydrochloric Acid SCHEMBL174764 | 0.74 | AURKA (0.49) | AURKAGRK6NTRK1PAK4JAK1 | |
| SCHEMBL17501774 | 0.70 | AURKA (0.53) | AURKANTRK1PAK4JAK1 | |
| SCHEMBL174676 | 0.70 | PLK4 (0.45) | AURKANTRK1PAK4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611502-A1 | ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030918-A1 | ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |