Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12089197 | 1.00 | MEN1 (0.36) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL15600496 | 0.81 | MEN1 (0.39) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL29791967 | 0.81 | MEN1 (0.39) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL1712001 | 0.81 | MEN1 (0.39) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL19099770 | 0.81 | CYP19A1 (0.35) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL16522638 | 0.78 | CYP19A1 (0.33) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL12088753 | 0.77 | KMT2A (0.36) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL12087968 | 0.76 | MEN1 (0.36) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL1711424 | 0.73 | MEN1 (0.36) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL12487361 | 0.72 | MEN1 (0.34) | MEN1KMT2AHTTMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935270-A1 | ARYL-SUBSTITUTED FUSED BICYCLIC PYRIDAZINE COMPOUNDS | Novartis AG (CH) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014099880-A1 | ARYL-SUBSTITUTED FUSED BICYCLIC PYRIDAZINE COMPOUNDS | NOVARTIS AG (CH) | 2014-06-26 | — | — | WO | disclosed |
| EP-2681197-A1 | TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012120415-A1 | TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |