Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522895 | 0.85 | FLT3 (0.63) | FLT3MAPK8MAPK9 | |
| SCHEMBL12272016 | 0.85 | FLT3 (0.63) | FLT3MAPK8MAPK9 | |
| SCHEMBL12272384 | 0.85 | FLT3 (0.80) | FLT3MAPK8MAPK9CDK1CCNE1 | |
| SCHEMBL12522785 | 0.85 | FLT3 (0.80) | FLT3MAPK8MAPK9CDK1CCNE1 | |
| SCHEMBL12522894 | 0.79 | FLT3 (0.83) | FLT3MAPK8MAPK9CCNE1CDK2 | |
| SCHEMBL12273002 | 0.79 | FLT3 (0.83) | FLT3MAPK8MAPK9CCNE1CDK2 | |
| SCHEMBL12272584 | 0.78 | FLT3 (0.71) | FLT3MAPK8MAPK9 | |
| SCHEMBL12522707 | 0.78 | FLT3 (0.71) | FLT3MAPK8MAPK9 | |
| SCHEMBL12272241 | 0.77 | FLT3 (0.82) | FLT3MAPK8MAPK9 | |
| SCHEMBL12490669 | 0.77 | FLT3 (0.57) | FLT3MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2686319-A1 | IMIDAZO PYRAZINES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012123470-A1 | IMIDAZO PYRAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |