Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | LYN | P07948 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 4/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.43 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12492967 | 0.85 | FYN (0.60) | FYNPTGS2LYNSRCPIP4K2A | |
| SCHEMBL12492080 | 0.84 | FYN (0.66) | FYNBTKLYNSRCCYP11B2 | |
| SCHEMBL27950283 | 0.83 | FYN (0.67) | FYNBTKLYNSRC | |
| SCHEMBL18613214 | 0.82 | FYN (1.00) | FYNBTKSRC | |
| SCHEMBL30521916 | 0.82 | FYN (1.00) | FYNBTKSRC | |
| SCHEMBL16331835 | 0.82 | FYN (0.81) | FYNBTKLYNSRCCYP11B2 | |
| SCHEMBL12492915 | 0.81 | FYN (0.83) | FYNLYNSRC | |
| SCHEMBL12492640 | 0.81 | FYN (0.66) | FYN | |
| SCHEMBL16331720 | 0.80 | FYN (1.00) | FYNBTKLYNSRCGSK3A | |
| SCHEMBL30521700 | 0.80 | FYN (1.00) | FYNBTKLYNSRCGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2686318-A1 | PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS | Cancer Research Technology Ltd (GB) | 2014-01-22 | — | — | EP | disclosed |
| CN-103517903-A | Pyrrolopyridineamino derivatives as MPS1 inhibitors | CANCER REC TECH LTD | 2014-01-15 | — | — | CN | disclosed |
| WO-2012123745-A1 | PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-09-20 | — | — | WO | disclosed |