Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 15/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | JUN | P05412 | 1/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12273168 | 0.86 | FLT3 (0.68) | MAPK9MAPK8MAPK10FLT3 | |
| SCHEMBL12522892 | 0.86 | FLT3 (0.68) | MAPK9MAPK8MAPK10FLT3 | |
| SCHEMBL183898 | 0.79 | MAPK8 (1.00) | MAPK9MAPK8MAPK10FLT3IRAK4 | |
| SCHEMBL7888011 | 0.79 | MAPK8 (1.00) | MAPK9MAPK8MAPK10FLT3IRAK4 | |
| SCHEMBL7884779 | 0.78 | MAPK9 (1.00) | MAPK9MAPK8MAPK10FLT3IRAK4 | |
| SCHEMBL183227 | 0.78 | MAPK9 (1.00) | MAPK9MAPK8MAPK10FLT3IRAK4 | |
| SCHEMBL12272958 | 0.75 | FLT3 (0.69) | MAPK9MAPK8MAPK10FLT3IRAK4 | |
| SCHEMBL7884533 | 0.74 | MAPK9 (1.00) | MAPK9MAPK8MAPK10FLT3IRAK4 | |
| SCHEMBL182900 | 0.74 | MAPK9 (1.00) | MAPK9MAPK8MAPK10FLT3IRAK4 | |
| SCHEMBL12272756 | 0.73 | FLT3 (0.81) | MAPK9MAPK8FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2686319-A1 | IMIDAZO PYRAZINES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012123470-A1 | IMIDAZO PYRAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |