Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18936954 | 0.84 | FGFR1 (0.48) | MAPK1FGFR1FGFR2FGFR3MAPKAPK2 | |
| SCHEMBL12495603 | 0.82 | MAPK1 (0.48) | MAPK1ATRMAPKAPK2PARP10PARP11 | |
| SCHEMBL12495496 | 0.81 | MAPK1 (0.44) | MAPK1ATRMAPKAPK2MAPK9PARP10 | |
| SCHEMBL18937020 | 0.79 | MAPK1 (0.45) | MAPK1ATRMAPKAPK2MAPK9PARP10 | |
| SCHEMBL27946388 | 0.79 | MAPK1 (0.49) | MAPK1MAPKAPK2MAPK9PARP10PARP11 | |
| SCHEMBL12077344 | 0.77 | MAPK1 (0.44) | MAPK1ATRMAPKAPK2MAPK9PARP10 | |
| SCHEMBL12077111 | 0.77 | MAPK1 (0.44) | MAPK1ATRMAPKAPK2MAPK9PARP10 | |
| SCHEMBL12077536 | 0.76 | MAP4K4 (0.45) | MAPK1MAPKAPK2MAPK9PARP10PARP11 | |
| SCHEMBL12495198 | 0.76 | MAPK1 (0.47) | MAPK1ATRMAPKAPK2MAPK9PARP10 | |
| SCHEMBL12495613 | 0.75 | MAPK1 (0.48) | MAPK1MAPKAPK2MAPK9PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2681206-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012121992-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |