Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 2/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523223 | 0.81 | KMT2A (0.55) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL21587681 | 0.79 | KMT2A (0.46) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL18410063 | 0.79 | KMT2A (0.46) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL49946 | 0.78 | KMT2A (0.57) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL24650964 | 0.75 | KMT2A (0.43) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL20865860 | 0.75 | KMT2A (0.43) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL22303034 | 0.74 | KMT2A (0.53) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL3268236 | 0.74 | KMT2A (0.57) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL26789473 | 0.74 | POLB (0.59) | KMT2APOLBHSP90AA1HSP90AB1OXTR | |
| SCHEMBL1682443 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230046093-A1 | PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF FORMULA (I) | ASTRAZENECA AB (SE) | 2023-02-16 | — | — | US | disclosed |
| US-20210188868-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF | JS INNOMED HOLDINGS LTD. (KY) | 2021-06-24 | — | — | US | disclosed |
| EP-3077401-B1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH INC (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-2681215-A1 | SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012118850-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046093-A1 | PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF FORMULA (I) | CYP2F1, CYP11B1, CYP4F11 | KMT2A 4222/4885POLB 1179/4885HSP90AA1 2665/4885 |
| US-20210188868-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF | MAP3K11, MAP3K13, MAP3K1 | KMT2A 1303/4885POLB 2479/4885HSP90AA1 1859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.