Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | FABP7 | O15540 | 3/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15768958 | 1.00 | TSHR (0.45) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL15783747 | 0.84 | FABP7 (0.60) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL14276798 | 0.83 | TSHR (0.60) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL5122894 | 0.83 | TSHR (0.60) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL15768614 | 0.83 | HDAC4 (0.59) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL15768992 | 0.82 | TSHR (0.53) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL12498187 | 0.82 | GAA (0.42) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL12694435 | 0.82 | GAA (0.42) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL15768581 | 0.81 | HDAC4 (0.61) | TSHRPPARGFABP7FABP5MEN1 | |
| SCHEMBL18462855 | 0.80 | GAA (0.63) | TSHRPPARGFABP7FABP5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2667709-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012103008-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2012-08-02 | — | — | WO | disclosed |