Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.63 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.57 |
| ▸ | EED | O75530 | 2/20 | 0.51 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.51 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.51 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.51 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591172 | 0.94 | EZH2 (0.64) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12498343 | 0.93 | EZH2 (0.62) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL2592844 | 0.92 | EZH2 (0.73) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12499929 | 0.91 | EZH2 (0.59) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL2586129 | 0.90 | EZH2 (0.75) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL30388272 | 0.90 | EZH2 (0.75) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684422 | 0.88 | EZH2 (0.56) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL2594868 | 0.88 | EZH2 (0.76) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL2586055 | 0.87 | EZH2 (0.69) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12684081 | 0.86 | EZH2 (0.54) | EZH2EZH1EEDRBBP4SUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681216-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012118812-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2012-09-07 | — | — | WO | disclosed |