Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 9/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL512835 | 0.82 | HRH3 (0.34) | HRH4HRH3 | |
| SCHEMBL511681 | 0.81 | HRH3 (0.32) | HRH4HRH3 | |
| SCHEMBL18559820 | 0.81 | HRH3 (0.41) | PDE10AHRH4HRH3 | |
| SCHEMBL511790 | 0.81 | HRH3 (0.35) | PDE10AHRH4HRH3 | |
| SCHEMBL512628 | 0.81 | CYP3A4 (0.34) | HRH4HRH3 | |
| SCHEMBL513595 | 0.80 | SMN1; SMN2 (0.43) | HRH4HRH3 | |
| SCHEMBL512509 | 0.80 | CYP3A4 (0.30) | — | |
| SCHEMBL511704 | 0.79 | MAOB (0.36) | FFAR2PDE10AHRH4HRH3 | |
| SCHEMBL18559791 | 0.79 | CYP3A4 (0.33) | HRH4HRH3 | |
| SCHEMBL512280 | 0.78 | GAK (0.38) | FFAR2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668168-A1 | COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012103297-A1 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-02 | — | — | WO | disclosed |