Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 1.00 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14053987 | 0.97 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL12502795 | 0.95 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL12503029 | 0.92 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL14054110 | 0.89 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL12502110 | 0.89 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL12502544 | 0.88 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL12502424 | 0.87 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL15471735 | 0.87 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL12502715 | 0.87 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL18861053 | 0.85 | PDE2A (1.00) | PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670754-B1 | (1,2,4)TRIAZOLO[4,3-A]QUINOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | BOEHRINGER INGELHEIM INT (DE) | 2017-05-24 | — | — | EP | claimed |
| EP-2670754-B1 | (1,2,4)TRIAZOLO[4,3-A]QUINOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | BOEHRINGER INGELHEIM INT (DE) | 2017-05-24 | — | — | EP | disclosed |
| EP-2670754-A1 | (1,2,4)TRIAZOLO[4,3-A]QUINOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | Boehringer Ingelheim International GmbH (DE) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104293-A1 | (1,2,4)TRIAZOLO[4,3-A]QUINOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-08-09 | — | — | WO | disclosed |