Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 5/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580336 | 0.89 | IGF1R (0.44) | IGF1RKMT2ALATS1SMYD3KDM4E | |
| SCHEMBL22411406 | 0.82 | MAPT (0.41) | SMYD3KDM4ENAMPTCHRNB2CHRNA7 | |
| SCHEMBL17541892 | 0.81 | SMYD3 (0.39) | SMYD3NAMPTCHRNB2CHRNA7CHRNA4 | |
| Hydrochloric Acid SCHEMBL21545777 | 0.80 | SMYD3 (0.39) | SMYD3NAMPTCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL30357995 | 0.80 | SMYD3 (0.56) | IGF1RKMT2ASMYD3KDM4EALDH1A1 | |
| SCHEMBL8567081 | 0.80 | SMYD3 (0.56) | IGF1RKMT2ASMYD3KDM4EALDH1A1 | |
| SCHEMBL926907 | 0.80 | SMYD3 (0.56) | IGF1RKMT2ASMYD3KDM4EALDH1A1 | |
| SCHEMBL7433964 | 0.80 | SMYD3 (0.56) | IGF1RKMT2ASMYD3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5424922 | 0.78 | SMYD3 (0.54) | IGF1RKMT2ASMYD3KDM4EALDH1A1 | |
| SCHEMBL13604128 | 0.78 | NAMPT (0.42) | IGF1RKMT2ALATS1KDM4ENAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670750-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | Fibrogen, Inc. (US) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012106472-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | FIBROGEN, INC. (US) | 2012-08-09 | — | — | WO | disclosed |