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SCHEMBL12505263

SCHEMBL12505263

[CH2]C(N1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCC([C@@H](O[Si](C)(C)C(C)(C)C)c5ccccc5-c5ccc(Cl)cc5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)CC1)(C(C)(C)C)C(C)(C)C

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BCL2L1 Q07817 20/20 0.75
▸ BCL2 P10415 19/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL554592 0.94 BCL2L1 (0.84) BCL2L1BCL2
SCHEMBL554591 0.94 BCL2L1 (0.84) BCL2L1BCL2
SCHEMBL554593 0.94 BCL2L1 (0.84) BCL2L1BCL2
SCHEMBL554812 0.91 BCL2L1 (0.73) BCL2L1BCL2
SCHEMBL553510 0.91 BCL2L1 (0.77) BCL2L1BCL2
SCHEMBL554813 0.91 BCL2L1 (0.73) BCL2L1BCL2
SCHEMBL553511 0.91 BCL2L1 (0.77) BCL2L1BCL2
SCHEMBL553512 0.91 BCL2L1 (0.77) BCL2L1BCL2
SCHEMBL554814 0.91 BCL2L1 (0.73) BCL2L1BCL2
SCHEMBL553551 0.89 BCL2L1 (0.86) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2601177-A1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS AstraZeneca AB (SE) 2013-06-12 — — EP disclosed
WO-2012017251-A1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS ASTRAZENECA AB (SE) 2012-02-09 — — WO disclosed
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