Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | SHH | Q15465 | 7/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2192016 | 1.00 | USP2 (0.64) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL2192022 | 1.00 | USP2 (0.64) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL12418065 | 1.00 | USP2 (0.64) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL17498002 | 0.94 | USP2 (0.64) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL17497999 | 0.94 | USP2 (0.64) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL2188419 | 0.86 | SHH (0.69) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL2188428 | 0.86 | SHH (0.69) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL17497323 | 0.86 | USP2 (0.67) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL17497608 | 0.86 | USP2 (0.67) | USP2SHHL3MBTL1AGTR1 | |
| SCHEMBL17497611 | 0.86 | USP2 (0.67) | USP2SHHL3MBTL1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-07-14 | — | — | US | disclosed |
| WO-2009132032-A2 | SONIC HEDGEHOG MODULATORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | SHH, GLI1, SMO | USP2 1861/4885SHH 1/4885L3MBTL1 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.