Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.73 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.73 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.73 |
| ▸ | INSR | P06213 | 1/20 | 0.73 |
| ▸ | GRK5 | P34947 | 2/20 | 0.64 |
| ▸ | GRK2 | P25098 | 1/20 | 0.64 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
| ▸ | ROS1 | P08922 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | FER | P16591 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12429667 | 0.92 | IGF1R (0.70) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429695 | 0.88 | IGF1R (0.73) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429419 | 0.86 | IGF1R (0.78) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429698 | 0.86 | IGF1R (0.69) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12430015 | 0.85 | IGF1R (0.81) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12430025 | 0.85 | IGF1R (0.81) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429417 | 0.85 | IGF1R (0.76) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL12429410 | 0.85 | IGF1R (0.76) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL11919217 | 0.84 | IGF1R (1.00) | IGF1RMAPK8MAPK10ALKINSR | |
| SCHEMBL14980817 | 0.84 | IGF1R (0.73) | IGF1RMAPK8MAPK10ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981903-B2 | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer | GLAXOSMITHKLINE LLC (US) | 2011-07-19 | — | — | US | disclosed |