Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.59 |
| ▸ | CDC7 | O00311 | 4/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.58 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.58 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL385067 | 0.87 | PIM1 (0.59) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL385492 | 0.86 | CDC7 (0.64) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL385178 | 0.85 | CDC7 (0.75) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL384783 | 0.81 | CDC7 (0.72) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL12514208 | 0.80 | CDC7 (0.66) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL384742 | 0.79 | PIM1 (0.72) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL383660 | 0.79 | PIM1 (0.65) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL19783008 | 0.78 | CXCL12 (0.74) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL14547357 | 0.77 | PIM1 (0.80) | PIM1CDC7CSNK2A2CLK1GSK3B | |
| SCHEMBL385827 | 0.77 | PIM1 (0.57) | PIM1CDC7CSNK2A2CLK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948617-B1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2011-07-27 | — | — | EP | disclosed |