Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 8/20 | 0.61 |
| ▸ | PPARG | P37231 | 11/20 | 0.57 |
| ▸ | PPARA | Q07869 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12629008 | 1.00 | FFAR1 (0.61) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL10223644 | 0.90 | PPARG (0.66) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL19217618 | 0.89 | FFAR1 (0.69) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL6928348 | 0.88 | PPARG (0.66) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL6929680 | 0.88 | PPARG (0.66) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL6929794 | 0.88 | PPARG (0.66) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL6931318 | 0.87 | PPARG (0.63) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL12628459 | 0.86 | PPARG (0.55) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL6931577 | 0.86 | FFAR1 (0.60) | FFAR1PPARGPPARACYP3A4MEN1 | |
| SCHEMBL16379095 | 0.83 | PPARG (0.64) | FFAR1PPARGPPARACYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3202401-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Octeta Therapeutics, LLC (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2011084453-A1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) | 2011-07-14 | — | — | WO | disclosed |