Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.49 |
| ▸ | CSK | P41240 | 3/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.49 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276365 | 0.94 | DDR1 (0.70) | DDR1MAPK14MAP3K7CSKMAP4K2 | |
| SCHEMBL22457387 | 0.85 | DDR1 (0.58) | DDR1MAPK14MAP3K7CSKMAP4K2 | |
| SCHEMBL2280488 | 0.83 | DDR1 (0.58) | DDR1RAD52 | |
| SCHEMBL12518257 | 0.83 | DDR1 (0.88) | DDR1KITCSF1RMAPK14MAP3K7 | |
| SCHEMBL2276363 | 0.81 | DDR1 (0.53) | DDR1MAPK14MAP3K7CSKMAP4K2 | |
| SCHEMBL2284120 | 0.77 | DDR1 (1.00) | DDR1MAPK14MAP3K7CSKMAP4K2 | |
| SCHEMBL17208616 | 0.75 | DDR1 (0.85) | DDR1MAPK14MAP3K7CSKMAP4K2 | |
| SCHEMBL17515255 | 0.75 | DDR1 (0.95) | DDR1MAPK14MAP3K7CSKMAP4K2 | |
| SCHEMBL2280492 | 0.74 | DDR1 (0.46) | DDR1MAPK14MAP3K7CSKMAP4K2 | |
| SCHEMBL26882862 | 0.72 | DDR1 (0.78) | DDR1MAPK14MAP3K7CSKMAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090738-A2 | TYPE II RAF KINASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-07-28 | — | — | WO | disclosed |