Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 11/20 | 0.35 |
| ▸ | MAPT | P10636 | 9/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1252727 | 0.81 | IDO1 (0.63) | IDO1GAAMAPTPOLBTDP1 | |
| SCHEMBL1253251 | 0.76 | IDO1 (0.53) | IDO1GAAMAPTPOLBKDM4E | |
| SCHEMBL4715055 | 0.74 | IDO1 (1.00) | IDO1GAAMAPTPOLBHSD17B10 | |
| SCHEMBL4715680 | 0.73 | IDO1 (0.62) | IDO1GAAMAPTPOLBTDP1 | |
| SCHEMBL4717796 | 0.73 | IDO1 (0.79) | IDO1GAAMAPTPOLBKDM4E | |
| SCHEMBL4716881 | 0.72 | IDO1 (0.69) | IDO1GAAMAPTPOLBTDP1 | |
| SCHEMBL4714747 | 0.71 | IDO1 (0.70) | IDO1GAAMAPTPOLBKDM4E | |
| SCHEMBL4716917 | 0.70 | IDO1 (0.69) | IDO1GAAMAPTPOLBKDM4E | |
| SCHEMBL4717242 | 0.70 | IDO1 (0.65) | IDO1GAAMAPTPOLBTDP1 | |
| SCHEMBL1250495 | 0.70 | IDO1 (0.58) | IDO1GAAMAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996596-B1 | SUBSTITUTED IMIDAZO(2,1-B)THIAZOLE COMPOUNDS AND THEIR USE FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2015-07-08 | — | — | EP | disclosed |
| US-7893069-B2 | Substituted imidazo[2,1-b]thiazole compounds and uses thereof | GRUENENTHAL GMBH (DE) | 2011-02-22 | — | — | US | disclosed |
| US-20090005399-A1 | Substituted Imidazo[2,1-b]thiazole Compounds and Uses Thereof | GRUENENTHAL GMBH (DE) | 2009-01-01 | — | — | US | disclosed |
| EP-1996596-A2 | SUBSTITUTED IMIDAZO(2,1-B)THIAZOLE COMPOUNDS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104485-A2 | SUBSTITUTED IMIDAZO[2,1-B]THIAZOLE COMPOUNDS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005399-A1 | Substituted Imidazo[2,1-b]thiazole Compounds and Uses Thereof | GRM5, GRIK5, GRM1 | IDO1 3418/4885GAA 4187/4885MAPT 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.