Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12523302 | 1.00 | JAK2 (0.38) | JAK2JAK1TSHR | |
| SCHEMBL12523343 | 1.00 | JAK2 (0.38) | JAK2JAK1TSHR | |
| SCHEMBL22778844 | 0.83 | JAK2 (0.34) | JAK2JAK1 | |
| SCHEMBL22855610 | 0.81 | TSHR (0.34) | TSHR | |
| SCHEMBL22752293 | 0.78 | — | — | |
| SCHEMBL22752505 | 0.78 | — | — | |
| SCHEMBL12524851 | 0.75 | — | — | |
| SCHEMBL12524324 | 0.74 | JAK2 (0.33) | JAK2JAK1TSHR | |
| SCHEMBL16330608 | 0.74 | JAK2 (0.33) | JAK2JAK1TSHR | |
| SCHEMBL12523410 | 0.74 | JAK2 (0.33) | JAK2JAK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3012258-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AND -TRIAZINES AS ANTIVIRAL AGENTS | Gilead Sciences, Inc. (US) | 2016-04-27 | — | — | EP | disclosed |
| EP-2585467-B1 | PYRAZOLO[1,5-A]PYRIMIDINES AND -TRIAZINES AS ANTIVIRAL AGENTS | GILEAD SCIENCES INC (US) | 2016-03-02 | — | — | EP | disclosed |