Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 10/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.37 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001676 | 0.84 | TTBK1 (0.41) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001602 | 0.83 | TTBK1 (0.39) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001493 | 0.83 | TTBK1 (0.39) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001458 | 0.83 | TTBK1 (0.40) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001595 | 0.82 | TTBK1 (0.41) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL11970756 | 0.82 | PAK4 (0.53) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001425 | 0.81 | MAP3K14 (0.42) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001568 | 0.81 | MAP3K14 (0.42) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001452 | 0.81 | MAP3K14 (0.42) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 | |
| SCHEMBL12001627 | 0.81 | TTBK1 (0.38) | TTBK1PAK4PIKFYVEMAP3K14TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012123522-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |