Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.59 |
| ▸ | CA9 | Q16790 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | STS | P08842 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12529071 | 0.90 | MCHR1 (0.57) | MAPTSMN1; SMN2TP53POLBPANK3 | |
| SCHEMBL12529014 | 0.89 | MCHR1 (0.65) | MAPTSMN1; SMN2PANK3CA2CA12 | |
| SCHEMBL12529049 | 0.89 | NOTUM (0.56) | MAPTSMN1; SMN2TP53POLBPANK3 | |
| SCHEMBL12529009 | 0.89 | MAPT (0.62) | MAPTSMN1; SMN2TP53POLBPANK3 | |
| SCHEMBL12529069 | 0.87 | MCHR1 (0.53) | MAPTSMN1; SMN2TP53POLBCA2 | |
| SCHEMBL12528808 | 0.86 | MCHR1 (0.56) | MAPTSMN1; SMN2POLBMCHR1ALDH1A1 | |
| SCHEMBL12529027 | 0.86 | MAPT (0.62) | MAPTSMN1; SMN2TP53POLBMCHR1 | |
| SCHEMBL12528993 | 0.86 | MCHR1 (0.65) | MAPTPOLBCA2CA12CA9 | |
| SCHEMBL14415286 | 0.86 | MCHR1 (0.56) | MAPTSMN1; SMN2TP53POLBPANK3 | |
| SCHEMBL12529006 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2MCHR1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968550-B2 | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2011-06-28 | — | — | US | disclosed |
| US-7968550-B2 | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2011-06-28 | — | — | US | disclosed |
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |
| US-7223788-B2 | therapy for eating disorders, anorexigenic agents, antidiabetic agents, reducing weight in mammals, circadian rhythm disease, psychological disorders | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |