Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 9/20 | 0.65 |
| ▸ | PRKDC | P78527 | 5/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12528826 | 0.83 | PTK2 (0.71) | PTK2CLK4USP2LMNACYP1A2 | |
| SCHEMBL12528777 | 0.82 | PTK2 (0.66) | PTK2PRKDCULK1P2RX7CLK4 | |
| SCHEMBL12528724 | 0.81 | PTK2 (0.71) | PTK2PRKDCULK1CSF1RCLK4 | |
| SCHEMBL12529142 | 0.78 | PTK2 (1.00) | PTK2CSF1RCLK4JAK2AURKA | |
| SCHEMBL12528689 | 0.75 | PTK2 (0.72) | PTK2PRKDCULK1CSF1RCLK4 | |
| SCHEMBL12529157 | 0.74 | PTK2 (0.66) | PTK2PRKDCCSF1RTTKP2RX7 | |
| SCHEMBL12528691 | 0.73 | PTK2 (1.00) | PTK2ULK1TTKJAK2 | |
| SCHEMBL12528754 | 0.73 | PTK2 (0.61) | PTK2PRKDCCSF1RTTKCLK4 | |
| SCHEMBL12528809 | 0.73 | PTK2 (0.68) | PTK2PRKDCULK1CSF1RCLK4 | |
| SCHEMBL12528728 | 0.73 | PTK2 (0.68) | PTK2PRKDCULK1CSF1RTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713806-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2013-05-08 | — | — | EP | disclosed |
| US-7968557-B2 | Diseases with abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, alpha and beta SAPK2 kinases; antiproliferative; pyrrolo[2,3-d]pyrimidine-7-carboxylic acid [3-phenylcarbamoyl-phenyl]-amides and pyrrolo[3,2-c]pyridine analogs | NOVARTIS AG (CH) | 2011-06-28 | — | — | US | disclosed |
| US-7968557-B2 | Diseases with abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, alpha and beta SAPK2 kinases; antiproliferative; pyrrolo[2,3-d]pyrimidine-7-carboxylic acid [3-phenylcarbamoyl-phenyl]-amides and pyrrolo[3,2-c]pyridine analogs | NOVARTIS AG (CH) | 2011-06-28 | — | — | US | disclosed |