Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 4/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751631 | 0.95 | ELANE (0.38) | MEN1KMT2AELANECMA1HRH2 | |
| SCHEMBL12529480 | 0.95 | ELANE (0.38) | MEN1KMT2AELANECMA1HRH2 | |
| SCHEMBL14001843 | 0.95 | ELANE (0.38) | MEN1KMT2AELANECMA1HRH2 | |
| SCHEMBL12021131 | 0.90 | ACACB (0.35) | MEN1KMT2AMCL1 | |
| SCHEMBL12021136 | 0.88 | XIAP (0.39) | MEN1KMT2AELANEHRH1 | |
| SCHEMBL1750899 | 0.88 | XIAP (0.39) | MEN1KMT2AELANEHRH1 | |
| SCHEMBL19696653 | 0.88 | XIAP (0.39) | MEN1KMT2AELANEHRH1 | |
| SCHEMBL12529508 | 0.84 | MEN1 (0.37) | MEN1KMT2AELANECMA1MCL1 | |
| SCHEMBL4456408 | 0.82 | USP30 (0.40) | MEN1KMT2AMCL1 | |
| SCHEMBL12021128 | 0.82 | MEN1 (0.33) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840464-B2 | IAP binding compounds | TetraLogic Birinapant UK Ltd. (GB) | 2017-12-12 | — | — | US | disclosed |
| US-20160289183-A1 | IAP Binding Compounds | TETRALOGIC PHARMACEUTICALS CORPORATION | 2016-10-06 | — | — | US | disclosed |
| US-9394249-B2 | IAP binding compounds | TetraLogic Birinapant UK Ltd. (GB) | 2016-07-19 | — | — | US | disclosed |
| US-20150307448-A1 | IAP Binding Compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2015-10-29 | — | — | US | disclosed |
| US-8802716-B2 | IAP binding compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-08-12 | — | — | US | disclosed |
| US-20130289075-A1 | IAP BINDING COMPOUNDS | TETRALOGIC PHARMACEUTICALS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-7968590-B2 | IAP binding compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-06-28 | — | — | US | disclosed |
| US-20090048183-A1 | IAP BINDING COMPOUNDS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2009-02-19 | — | — | US | disclosed |
| US-7456209-B2 | IAP binding compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2008-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289183-A1 | IAP Binding Compounds | BIRC5, API5, BIRC2 | MEN1 2970/4885KMT2A 4634/4885ELANE 426/4885 |
| US-20130289075-A1 | IAP BINDING COMPOUNDS | API5, BIRC5, BIRC2 | MEN1 3007/4885KMT2A 4596/4885ELANE 435/4885 |
| US-20150307448-A1 | IAP Binding Compounds | BIRC5, API5, BIRC2 | MEN1 2970/4885KMT2A 4634/4885ELANE 426/4885 |
| US-20090048183-A1 | IAP BINDING COMPOUNDS | BIRC5, BIRC2, API5 | MEN1 2999/4885KMT2A 4541/4885ELANE 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.