Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 8/20 | 0.59 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.51 |
| ▸ | CDK2 | P24941 | 9/20 | 0.51 |
| ▸ | CDK9 | P50750 | 9/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913585 | 0.94 | PDPK1 (0.58) | PDPK1SGK1CCNT1CCNA2CDK2 | |
| SCHEMBL13555217 | 0.94 | PDPK1 (0.58) | PDPK1SGK1CCNT1CCNA2CDK2 | |
| SCHEMBL13385920 | 0.91 | PDPK1 (0.56) | PDPK1SGK1CCNT1CCNA2CDK2 | |
| SCHEMBL1913530 | 0.85 | PDPK1 (0.73) | PDPK1 | |
| SCHEMBL1913422 | 0.85 | PDPK1 (0.50) | PDPK1SGK1CCNT1CCNA2CDK2 | |
| SCHEMBL12530673 | 0.85 | PDPK1 (0.50) | PDPK1SGK1CCNT1CCNA2CDK2 | |
| SCHEMBL1913629 | 0.85 | PDPK1 (0.68) | PDPK1CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL1913565 | 0.79 | PDPK1 (0.72) | PDPK1SGK1CCNT1CCNA2CDK2 | |
| SCHEMBL12530970 | 0.79 | PDPK1 (0.57) | PDPK1PIK3CA | |
| SCHEMBL1913645 | 0.78 | PDPK1 (0.75) | PDPK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076316-A1 | PYRROLOPYRIDINYL-PYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-06-30 | — | — | WO | disclosed |