⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29799920 | 1.00 | — | — | |
| SCHEMBL1092656 | 1.00 | — | — | |
| SCHEMBL12315223 | 1.00 | — | — | |
| SCHEMBL1093387 | 0.93 | — | — | |
| SCHEMBL13519223 | 0.88 | — | — | |
| SCHEMBL13519224 | 0.88 | — | — | |
| SCHEMBL16941416 | 0.87 | — | — | |
| SCHEMBL1254837 | 0.86 | — | — | |
| SCHEMBL1093140 | 0.86 | — | — | |
| SCHEMBL4095661 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9862737-B2 | Salts, prodrugs and polymorphs of fab I inhibitors | DEBIOPHARM INTERNATIONAL SA (CH) | 2018-01-09 | — | — | US | disclosed |
| US-20140309191-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2014-10-16 | — | — | US | disclosed |
| EP-1575951-B1 | HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY | DEBIOPHARM INT SA (CH) | 2014-06-25 | — | — | EP | disclosed |
| US-20130150400-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2013-06-13 | — | — | US | disclosed |
| US-8263613-B2 | Salts, prodrugs and polymorphs of fab I inhibitors | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2012-09-11 | — | — | US | disclosed |
| US-20120010127-A1 | Compositions Comprising Multiple Bioactive Agents, and Methods of Using the Same | BERMAN JUDD M (CA) | 2012-01-12 | — | — | US | disclosed |
| US-20110124633-A1 | Heterocyclic Compounds, Methods of Making Them and Their Use in Therapy | BERMAN JUDD | 2011-05-26 | — | — | US | disclosed |
| US-7879872-B2 | comprising (E)-N-methyl-N-(3-methylbenzofuran-2-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide or pharmaceutically acceptable salts thereof; and gentamicin; wherein combination has an fractional inhibitory coconcentration index value of 0.3 against S. aureus 29213 | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2011-02-01 | — | — | US | disclosed |
| US-7790709-B2 | inhibitors of bacterial enzymes such as (E)-3-(3,3-Dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido [2,3-e][1,4]diazepin-7-yl)-N-methyl-N-(3-methyl-benzofuran-2-ylmethyl)acrylamide, used as antibiotics | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2010-09-07 | — | — | US | disclosed |
| EP-2125802-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | Affinium Pharmaceuticals, Inc. (CA) | 2009-12-02 | — | — | EP | disclosed |
| US-20090042927-A1 | Salts, Prodrugs and Polymorphs of Fab I Inhibitors | DEBIOPHARM INTERNATIONAL SA (CH) | 2009-02-12 | — | — | US | disclosed |
| EP-1608377-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF FAB I AND FURTHER ANTIBIOTICS | AFFINIUM PHARM INC (CA) | 2008-10-01 | — | — | EP | disclosed |
| WO-2008098374-A1 | SALTS, PRODRUGS AND POLYMORPHS OF FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2008-08-21 | — | — | WO | disclosed |
| US-20060183908-A1 | inhibitors of bacterial enzymes such as (E)-3-(3,3-Dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido [2,3-e][1,4]diazepin-7-yl)-N-methyl-N-(3-methyl-benzofuran-2-ylmethyl)acrylamide, used as antibiotics | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2006-08-17 | — | — | US | disclosed |
| US-20060142265-A1 | Compositions comprising multiple bioactive agents, and methods of using the same | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2006-06-29 | — | — | US | disclosed |
| EP-1608377-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF FAB I AND FURTHER ANTIBIOTICS | Affinium Pharmaceuticals, Inc. (CA) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004082586-A2 | PHAMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF FAB I AND FURTHER ANTIBIOTICS | AFFINIUM PHARMACEUTICALS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |