Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.59 |
| ▸ | GSK3B | P49841 | 8/20 | 0.59 |
| ▸ | PIM1 | P11309 | 7/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.59 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215452 | 0.85 | PIK3CD (0.68) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL2214448 | 0.84 | PIK3CD (0.67) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL12542677 | 0.84 | PIK3CD (0.60) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL1961447 | 0.82 | PIK3CD (0.68) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL1959727 | 0.82 | PIK3CD (0.64) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL1958477 | 0.81 | PIK3CD (0.64) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL2212954 | 0.81 | PIK3CD (0.71) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL456977 | 0.79 | PIK3CD (0.64) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL1780205 | 0.79 | PIK3CD (0.64) | PIK3CDPIK3CBGSK3BPIM1PIK3CG | |
| SCHEMBL2214497 | 0.79 | PIK3CD (0.61) | PIK3CDPIK3CBGSK3BPIM1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2012-09-27 | — | — | US | claimed |
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2012-09-27 | — | — | US | disclosed |
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2012-09-27 | — | — | US | disclosed |
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LIMITED (GB) | 2012-09-27 | — | — | US | disclosed |
| WO-2011067365-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245171-A1 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES | PIK3C3, PIK3CA, PIK3CD | PIK3CD 3/4885PIK3CB 5/4885GSK3B 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.