SCHEMBL1255602

SCHEMBL1255602

C1CCC(=NN=C2CCCCC2)CC1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.53
CASP1 P29466 1/20 0.53
ALDH1A1 P00352 1/20 0.35
TRIM24 O15164 1/20 0.35
TRIM33 Q9UPN9 1/20 0.35
GAA P10253 2/20 0.31
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1255633 1.00 TSHR (0.53) TSHRCASP1ALDH1A1TRIM24TRIM33
SCHEMBL1255062 1.00 TSHR (0.53) TSHRCASP1ALDH1A1TRIM24TRIM33
SCHEMBL5879267 1.00 TSHR (0.53) TSHRCASP1ALDH1A1TRIM24TRIM33
SCHEMBL5879197 1.00 TSHR (0.53) TSHRCASP1ALDH1A1TRIM24TRIM33
SCHEMBL1255020 1.00 TSHR (0.53) TSHRCASP1ALDH1A1TRIM24TRIM33
SCHEMBL5879245 1.00 TSHR (0.53) TSHRCASP1ALDH1A1TRIM24TRIM33
SCHEMBL1255061 1.00 TSHR (0.53) TSHRCASP1ALDH1A1TRIM24TRIM33
Hydrochloric Acid SCHEMBL11633145 0.96 TSHR (0.50) TSHRCASP1ALDH1A1TRIM24TRIM33
SCHEMBL1254917 0.96 TSHR (0.47) TSHRCASP1TRIM24TRIM33GAA
SCHEMBL16438928 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8183326-B2 A living polymer endcapped with an azine compound; uniformly distributed reinforcing particulate fillers; tire treads with increased balance between rolling resistance and traction BRIDGESTONE CORPORATION (JP) 2012-05-22 US claimed
US-20070149717-A1 Functionalized polymers BRIDGESTONE CORPORATION (JP) 2007-06-28 US claimed
EP-0963979-B1 Method of producing 1,2,4-triazole starting from ketazin MITSUBISHI GAS CHEMICAL CO (JP) 2006-12-27 EP claimed
EP-0963979-A1 Method of producing 1,2,4-triazole starting from ketazin MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1999-12-15 EP claimed
US-6002015-A Method of producing 1,2,4-triazole MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1999-12-14 US claimed
EP-0051802-B1 PROCESS FOR THE PREPARATION OF AROMATIC AMINES HOECHST AKTIENGESELLSCHAFT (DE) 1985-01-23 EP claimed
US-3959343-A FROM KETAZINE AND HYDROGEN CYANIDE WAKO PURE CHEMICAL INDUSTRIES, LTD. (JA) 1976-05-25 US claimed
EP-1214353-B1 PROCESS FOR THE HYDROGENATION OF A POLYMER COMPOSED OF DIENE MONOMER UNITS AND A NITRILE GROUP-CONTAINING MONOMER UNITS ZEON CORP (JP) 2011-06-01 EP disclosed
US-7879952-B2 Functionalized polymers BRIDGESTONE CORPORATION (JP) 2011-02-01 US disclosed
EP-1803740-B1 Method for preparing functionalized polymers BRIDGESTONE CORP (JP) 2009-03-18 EP disclosed
EP-1803740-A1 Functionalized polymers Bridgestone Corporation (JP) 2007-07-04 EP disclosed
US-20070149717-A1 Functionalized polymers BRIDGESTONE CORPORATION (JP) 2007-06-28 US disclosed
EP-0963979-B1 Method of producing 1,2,4-triazole starting from ketazin MITSUBISHI GAS CHEMICAL CO (JP) 2006-12-27 EP disclosed
US-3972876-A Process for the preparation of symmetrical and unsymmetrical azines and mixtures thereof PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1976-08-03 US disclosed
US-3959262-A Method for preparing azines PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1976-05-25 US disclosed
US-3959343-A FROM KETAZINE AND HYDROGEN CYANIDE WAKO PURE CHEMICAL INDUSTRIES, LTD. (JA) 1976-05-25 US disclosed
US-3951964-A Method for preparing azines PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1976-04-20 US disclosed
US-3948902-A Method for preparing azines PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1976-04-06 US disclosed
US-3943132-A Process for the preparation of hydrazones PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1976-03-09 US disclosed
US-3939147-A Novel 1,2-diaza-1,5,9-cyclo dodecatrienes and 1,2-diaza-1-cyclododecenes CIBA-GEIGY CORPORATION (US) 1976-02-17 US disclosed