Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.51 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 2/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12562879 | 0.96 | EGFR (0.49) | EGFRERBB3ERBB2ERBB4ALK | |
| SCHEMBL12562693 | 0.94 | EGFR (0.48) | EGFRERBB3ERBB2ERBB4ALK | |
| SCHEMBL16200504 | 0.90 | ALK (0.51) | EGFRERBB3ALKGAKFES | |
| SCHEMBL12562675 | 0.90 | PTK2 (0.54) | ALKPTK2 | |
| SCHEMBL12562365 | 0.88 | LRRK2 (0.56) | ALKJAK3PTK2 | |
| SCHEMBL12562747 | 0.88 | MAPK3 (0.54) | ALKPTK2MAPK3 | |
| SCHEMBL12562685 | 0.87 | ALK (0.69) | ALKMAPK3 | |
| SCHEMBL12562970 | 0.86 | EGFR (0.48) | EGFRERBB3ERBB2ERBB4ALK | |
| SCHEMBL12562887 | 0.86 | EGFR (0.60) | EGFRALKPTK2 | |
| SCHEMBL12562744 | 0.85 | LRRK2 (0.65) | ALKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435411-B1 | 2,4-DIAMINOPYRIMIDINES FOR THE TREATMENT OF DISEASES CHARACTERISED BY EXCESSIVE OR ABNORMAL CELL PROLIFERATION | BOEHRINGER INGELHEIM INT (DE) | 2014-10-29 | — | — | EP | disclosed |
| US-8410126-B2 | Pyrimidine inhibitors of PKTK2 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| US-20110130401-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130401-A1 | NEW CHEMICAL COMPOUNDS | RB1, MKI67, CCNA1 | EGFR 592/4885ERBB3 1176/4885ERBB2 1008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.