Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.72 |
| ▸ | EDNRB | P24530 | 3/20 | 0.63 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | DHPS | P49366 | 1/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.61 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15257225 | 0.90 | EDNRA (0.61) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL914924 | 0.90 | EDNRA (0.75) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7830281 | 0.88 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL15279583 | 0.88 | EDNRA (0.61) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL1259727 | 0.87 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL3667814 | 0.85 | EDNRA (0.56) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL13281278 | 0.84 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| Water SCHEMBL1009968 | 0.83 | EDNRA (0.98) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL1938981 | 0.82 | EDNRA (0.78) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL3417934 | 0.82 | EDNRA (0.54) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011021216-A2 | IMPROVED PROCESS FOR THE PREPARATION OF 4-(1,1-DIMETHYLETHYL)-N-[6-(2-HYDROXYETHOXY)-5-(2-METHOXYPHENOXY)[2,2'-BIPYRIMIDIN]-4-YL]BENZENESULFONAMIDE | MSN LABORATORIES LIMITED (IN) | 2011-02-24 | — | — | WO | disclosed |