Ranolazine

SCHEMBL12590701

[2H]OC([2H])(C([2H])([2H])Oc1c([2H])c([2H])c([2H])c([2H])c1OC([2H])([2H])[2H])C([2H])([2H])N1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C(=O)N([2H])c2c(C([2H])([2H])[2H])c([2H])c([2H])c([2H])c2C([2H])([2H])[2H])C([2H])([2H])C1([2H])[2H]

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN4A SCN5A

The experimentally established mechanism targets of Ranolazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Ranolazine SCHEMBL12590711	0.82	CYP3A4 (0.33)	—
SCHEMBL12590709	0.77	—	—
Ranolazine SCHEMBL13991340	0.71	CYP3A4 (0.41)	—
Ranolazine SCHEMBL13991339	0.67	CYP3A4 (0.44)	—
Ranolazine SCHEMBL13991380	0.66	CYP3A4 (0.48)	—
Ranolazine SCHEMBL13991243	0.64	CYP3A4 (0.53)	—
Ranolazine SCHEMBL13991267	0.64	TSHR (0.52)	—
Ranolazine SCHEMBL13991301	0.64	DRD3 (0.48)	—
Ranolazine SCHEMBL13991257	0.63	CYP3A4 (0.51)	—
Ranolazine SCHEMBL13991276	0.63	TSHR (0.54)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20110160154-A1	SUBSTITUTED PIPERAZINES	AUSPEX PHARMACEUTICALS, INC. (US)	2011-06-30	—	—	US	disclosed
US-20080312247-A1	SUBSTITUTED PIPERAZINES	AUSPEX PHARMACEUTICALS, INC. (US)	2008-12-18	—	—	US	disclosed