Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.58 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | CDK7 | P50613 | 5/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.44 |
| ▸ | GSK3A | P49840 | 4/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.41 |
| ▸ | AURKA | O14965 | 5/20 | 0.40 |
| ▸ | RET | P07949 | 5/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605918 | 0.85 | SYK (0.53) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL12606292 | 0.85 | SYK (0.61) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL7168366 | 0.85 | IGF1R (0.61) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL1777884 | 0.84 | IGF1R (0.63) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL12606282 | 0.83 | SYK (0.58) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL1778861 | 0.82 | IGF1R (0.61) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL12606271 | 0.81 | SYK (0.66) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL1778605 | 0.81 | SYK (0.61) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL5618430 | 0.79 | SYK (0.58) | IGF1RSYKAURKBGSK3BCDK7 | |
| SCHEMBL1778196 | 0.79 | IGF1R (0.67) | IGF1RSYKAURKBGSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |