Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.63 |
| ▸ | IGF1R | P08069 | 5/20 | 0.62 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | CDK7 | P50613 | 5/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | GSK3A | P49840 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.45 |
| ▸ | RET | P07949 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | PAK4 | O96013 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777660 | 0.84 | IGF1R (0.67) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL1777888 | 0.83 | IGF1R (0.65) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL1777423 | 0.82 | IGF1R (0.67) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL22067931 | 0.82 | IGF1R (0.67) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL1776843 | 0.81 | SYK (0.61) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL1778206 | 0.81 | SYK (0.61) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL1778784 | 0.80 | SYK (0.71) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL28757494 | 0.80 | IGF1R (0.62) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL12606269 | 0.80 | IGF1R (0.62) | SYKIGF1RGSK3BCDK7AURKB | |
| SCHEMBL1779125 | 0.80 | SYK (0.71) | SYKIGF1RGSK3BCDK7AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |