Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.74 |
| ▸ | GSK3A | P49840 | 8/20 | 0.74 |
| ▸ | IGF1R | P08069 | 3/20 | 0.74 |
| ▸ | LCK | P06239 | 2/20 | 0.74 |
| ▸ | CDK7 | P50613 | 2/20 | 0.74 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.74 |
| ▸ | JAK2 | O60674 | 1/20 | 0.74 |
| ▸ | BTK | Q06187 | 1/20 | 0.74 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778085 | 0.88 | GSK3B (0.73) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL1780099 | 0.86 | GSK3B (0.70) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL1778128 | 0.86 | GSK3B (0.70) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL1777906 | 0.86 | GSK3B (0.67) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL1778596 | 0.85 | GSK3B (1.00) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL12606257 | 0.85 | IGF1R (0.58) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL1777901 | 0.82 | GSK3B (0.64) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL1779842 | 0.81 | GSK3B (0.62) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL1779102 | 0.81 | KDM4E (0.55) | GSK3BGSK3AIGF1RLCKCDK7 | |
| SCHEMBL5619401 | 0.81 | GSK3B (0.71) | GSK3BGSK3AIGF1RLCKCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |