Sugi Predict

Sugi Predict / Compounds / SCHEMBL12608693

SCHEMBL12608693

SCHEMBL12608693

C=C(C)c1cc2c3cc(C(C)=O)c(O)cc3n(CCCN(C)C)c2cc1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 1/20 0.39
▸ WEE1 P30291 4/20 0.36
▸ LMNA P02545 2/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ CYP2D6 P10635 2/20 0.34
▸ CHEK1 O14757 3/20 0.33
▸ SRC P12931 2/20 0.33
▸ CSF1R P07333 1/20 0.33
▸ PRNP P04156 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32
▸ CHRM2 P08172 1/20 0.32
▸ HTR1A P08908 1/20 0.32
▸ ADRA2A P08913 1/20 0.32
▸ CHRM1 P11229 1/20 0.32
▸ DRD2 P14416 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ DRD1 P21728 1/20 0.32
▸ TBXA2R P21731 1/20 0.32
▸ SLC6A2 P23975 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2360961 0.94 CNR2 (0.42) CNR2WEE1LMNACYP3A4CYP2D6
SCHEMBL17297962 0.88 CNR2 (0.41) CNR2WEE1LMNACYP2D6CHEK1
SCHEMBL21441035 0.83 CNR2 (0.36) CNR2WEE1LMNACYP2D6CHEK1
SCHEMBL17297929 0.80 CNR2 (0.45) CNR2WEE1LMNACYP2D6CSF1R
SCHEMBL18969217 0.78 WEE1 (0.37) CNR2WEE1CHEK1SRC
SCHEMBL2361620 0.77 SMPD1 (0.40) CNR2WEE1CYP3A4CYP1A2HTT
SCHEMBL12608686 0.77 WEE1 (0.44) CNR2WEE1CHEK1SRCCSF1R
SCHEMBL12608695 0.77 CYP3A4 (0.36) LMNACYP3A4MAPTCYP2D6SRC
SCHEMBL12608681 0.76 WEE1 (0.43) CNR2WEE1CHEK1SRCCSF1R
SCHEMBL18975619 0.75 WEE1 (0.39) CNR2WEE1CHEK1SRCCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2017-06-15 — — US disclosed
US-9108916-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2015-08-18 — — US disclosed
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, LLC (US) 2014-10-09 — — US disclosed
US-8765738-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2014-07-01 — — US disclosed
US-8486697-B2 Inducing cell death by inhibiting adaptive heat shock response INCURON, LLC (US) 2013-07-16 — — US disclosed
US-20110124104-A1 INDUCING CELL DEATH BY INHIBITING ADAPTIVE HEAT SHOCK RESPONSE INCURON, INC. 2011-05-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 CNR2 558/4885WEE1 1071/4885LMNA 4194/4885
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 CNR2 558/4885WEE1 1071/4885LMNA 4194/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.