Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.59 |
| ▸ | CDK2 | P24941 | 6/20 | 0.58 |
| ▸ | CDK4 | P11802 | 5/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 4/20 | 0.56 |
| ▸ | BCR | P11274 | 3/20 | 0.56 |
| ▸ | PRKCA | P17252 | 3/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 9/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CDK7 | P50613 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CCNH | P51946 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2541907 | 0.89 | GSK3B (0.60) | GSK3BCDK2CDK4SLC2A1ABL1 | |
| SCHEMBL2543297 | 0.83 | ABL1 (0.57) | GSK3BCDK2CDK4SLC2A1ABL1 | |
| SCHEMBL2539834 | 0.76 | MKNK2 (0.62) | GSK3BCDK2CDK4MKNK1MKNK2 | |
| SCHEMBL12611335 | 0.75 | CDK1 (0.69) | GSK3BCDK2SLC2A1MKNK2EGFR | |
| SCHEMBL4513070 | 0.74 | ABL1 (0.64) | GSK3BCDK2CDK4SLC2A1ABL1 | |
| SCHEMBL4478642 | 0.74 | CDK2 (1.00) | GSK3BCDK2CDK4SLC2A1ABL1 | |
| SCHEMBL2545958 | 0.74 | CDK1 (0.61) | GSK3BCDK2SLC2A1MKNK1MKNK2 | |
| SCHEMBL27809421 | 0.73 | GSK3B (0.61) | GSK3BCDK2CDK4MKNK1MKNK2 | |
| SCHEMBL1886 | 0.73 | ABL1 (1.00) | GSK3BCDK2CDK4SLC2A1ABL1 | |
| SCHEMBL4737544 | 0.73 | CDK2 (0.65) | GSK3BCDK2CDK4SLC2A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012126181-A1 | USE OF KINASE INHIBITORS IN PREVENTING AND TREATING INFLAMMATORY DISORDER | LUO YING (CN) | 2012-09-27 | — | — | WO | disclosed |