Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 6/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994802 | 0.94 | IRAK4 (0.47) | IRAK4IRAK1FLT3EIF2AK4PLA2G1B | |
| SCHEMBL12643906 | 0.94 | IRAK4 (0.47) | IRAK4IRAK1FLT3EIF2AK4PLA2G1B | |
| SCHEMBL13505191 | 0.87 | IRAK4 (0.50) | IRAK4IRAK1FLT3EIF2AK4EGLN2 | |
| SCHEMBL12643905 | 0.86 | IRAK4 (0.47) | IRAK4IRAK1FLT3EIF2AK4EGLN2 | |
| SCHEMBL12643668 | 0.86 | IRAK4 (0.47) | IRAK4IRAK1FLT3EIF2AK4EGLN2 | |
| SCHEMBL1992612 | 0.84 | FLT3 (0.53) | IRAK4IRAK1FLT3JAK2JAK1 | |
| SCHEMBL12643901 | 0.84 | IRAK4 (0.47) | IRAK4IRAK1FLT3EIF2AK4EGLN2 | |
| SCHEMBL1994106 | 0.84 | IRAK4 (0.47) | IRAK4IRAK1FLT3EIF2AK4EGLN2 | |
| SCHEMBL1993495 | 0.84 | IRAK4 (0.47) | IRAK4IRAK1FLT3EIF2AK4EGLN2 | |
| SCHEMBL1992529 | 0.84 | FLT3 (0.53) | IRAK4IRAK1FLT3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |