Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9477242 | 0.85 | KMT2A (0.70) | KMT2AGAANHERF1LMNAALDH1A1 | |
| SCHEMBL16166426 | 0.85 | KMT2A (0.70) | KMT2AGAANHERF1LMNAALDH1A1 | |
| SCHEMBL18770380 | 0.83 | KMT2A (0.51) | KMT2AGAANHERF1LMNAALDH1A1 | |
| SCHEMBL2589383 | 0.83 | KMT2A (0.67) | KMT2AGAANHERF1LMNAALDH1A1 | |
| SCHEMBL10153945 | 0.82 | CA1 (0.59) | GAALMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9417503 | 0.82 | KMT2A (0.66) | KMT2AGAANHERF1LMNAALDH1A1 | |
| SCHEMBL29504635 | 0.82 | CA1 (0.79) | KMT2AGAALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL63779 | 0.81 | KMT2A (0.64) | KMT2AGAANHERF1LMNAALDH1A1 | |
| SCHEMBL11292601 | 0.81 | KMT2A (0.64) | KMT2AGAANHERF1LMNAALDH1A1 | |
| SCHEMBL18770390 | 0.80 | KMT2A (0.49) | KMT2AGAANHERF1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169260-B2 | Amidopyrazole inhibitors of interleukin receptor-associated kinases | MERCK SHARP & DOHME CORP. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140194404-A1 | AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES | MERCK SHARP & DOHME LLC | 2014-07-10 | — | — | US | disclosed |
| EP-2688872-A1 | AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES | Merck Sharp & Dohme Corp. (US) | 2014-01-29 | — | — | EP | disclosed |
| WO-2012129258-A1 | AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES | MERCK SHARP & DOHME CORP. (US) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194404-A1 | AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES | IRAK4, IRAK3, IRAK1 | KMT2A 1386/4885GAA 3636/4885NHERF1 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.