Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 5/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | BLK | P51451 | 2/20 | 0.42 |
| ▸ | CCNH | P51946 | 2/20 | 0.42 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12615082 | 0.89 | FYN (0.53) | MKNK1IRAK4FLT3IRAK1LCK | |
| SCHEMBL12611013 | 0.89 | MAPK8 (0.48) | MKNK1IRAK4FLT3IRAK1LCK | |
| SCHEMBL1997583 | 0.84 | IRAK4 (0.60) | MKNK1IRAK4CTSKFLT3IRAK1 | |
| SCHEMBL12643896 | 0.84 | KIT (0.42) | IRAK4EIF2AK4 | |
| SCHEMBL12616146 | 0.84 | EIF2AK4 (0.49) | EIF2AK4 | |
| SCHEMBL12611153 | 0.82 | EIF2AK4 (0.43) | IRAK4EIF2AK4 | |
| SCHEMBL12643881 | 0.81 | EIF2AK4 (0.43) | FLT3EIF2AK4 | |
| SCHEMBL12614361 | 0.81 | EIF2AK4 (0.43) | IRAK4FLT3EIF2AK4 | |
| SCHEMBL12614083 | 0.81 | EIF2AK4 (0.46) | IRAK4FLT3EIF2AK4 | |
| SCHEMBL12615626 | 0.81 | JAK2 (0.42) | EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |