Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 8/20 | 0.52 |
| ▸ | ICOS | Q9Y6W8 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 9/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619636 | 0.91 | ICOSLG (0.54) | ICOSLGICOSPOLBCHUKKMT2A | |
| SCHEMBL12619653 | 0.90 | ICOSLG (0.52) | ICOSLGICOSPOLBCHUKKMT2A | |
| SCHEMBL12619639 | 0.89 | ICOSLG (0.56) | ICOSLGICOSCHUKKMT2AMEN1 | |
| SCHEMBL12619624 | 0.89 | ICOSLG (0.56) | ICOSLGICOSCHUKKMT2AMEN1 | |
| SCHEMBL1800310 | 0.89 | ICOSLG (0.60) | ICOSLGICOSCHUKKMT2AMEN1 | |
| SCHEMBL12619566 | 0.89 | ICOSLG (0.52) | ICOSLGICOSPOLBCHUKKMT2A | |
| SCHEMBL12619518 | 0.89 | ICOSLG (0.57) | ICOSLGICOSCHUKKMT2AALDH1A1 | |
| SCHEMBL1798960 | 0.88 | ICOSLG (0.61) | ICOSLGICOSCHUKKMT2AMEN1 | |
| SCHEMBL1798347 | 0.87 | ICOSLG (0.56) | ICOSLGICOSCHUKKMT2AALDH1A1 | |
| SCHEMBL12619445 | 0.87 | ICOSLG (0.56) | ICOSLGICOSCHUKKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951801-B2 | For therapy of inflammatory disease and cancer | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |