Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | UBE2D3 | P61077 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23107237 | 0.90 | MAPT (0.47) | MAPTRAB9ANPC1XBP1HTT | |
| SCHEMBL29383396 | 0.90 | MAPT (0.47) | MAPTRAB9ANPC1XBP1HTT | |
| SCHEMBL14947797 | 0.90 | MAPT (0.47) | MAPTRAB9ANPC1XBP1HTT | |
| SCHEMBL24246322 | 0.90 | MAPT (0.47) | MAPTRAB9ANPC1XBP1HTT | |
| SCHEMBL29379738 | 0.90 | MAPT (0.47) | MAPTRAB9ANPC1XBP1HTT | |
| SCHEMBL24246204 | 0.72 | SMN1; SMN2 (0.34) | CYP2C19 | |
| SCHEMBL23106956 | 0.72 | SMN1; SMN2 (0.34) | CYP2C19 | |
| SCHEMBL29382094 | 0.72 | SMN1; SMN2 (0.34) | CYP2C19 | |
| SCHEMBL23106927 | 0.72 | SMN1; SMN2 (0.34) | CYP2C19 | |
| SCHEMBL29380272 | 0.72 | SMN1; SMN2 (0.34) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951406-B2 | Demonstrate cytotoxic activity against a variety of cell types exhibiting hyperproliferative cell division; anticarcinogenic agents; ovarian cancer; naphtho(2,3-b)furan derivatives | CAROLINE VAN HAAFTEN (NL) | 2011-05-31 | — | — | US | disclosed |
| US-7951406-B2 | Demonstrate cytotoxic activity against a variety of cell types exhibiting hyperproliferative cell division; anticarcinogenic agents; ovarian cancer; naphtho(2,3-b)furan derivatives | CAROLINE VAN HAAFTEN (NL) | 2011-05-31 | — | — | US | disclosed |
| US-20080233214-A1 | Therapeutic Compounds Isolated from Calomeria Amaranthoides | VAN HAAFTEN CAROLINE | 2008-09-25 | — | — | US | disclosed |
| US-20080233214-A1 | Therapeutic Compounds Isolated from Calomeria Amaranthoides | VAN HAAFTEN CAROLINE | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080233214-A1 | Therapeutic Compounds Isolated from Calomeria Amaranthoides | MKI67, CALU, CALR | MAPT 2702/4885RAB9A 2586/4885NPC1 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.